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Huntington disease

  • IASbaba
  • March 21, 2020
  • 0
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Huntington disease

Part of: GS Prelims and GS-II- Health

  • Huntington disease (HD) is a progressive genetic disorder affecting the brain 
  • It causes uncontrolled movements, impaired coordination of balance and movement, a decline in cognitive abilities, difficulty in concentrating and memory lapses, mood swings and personality changes

How is the disease caused?

  • A gene called HTT are involved in the production of a protein called huntingtin.
  • When these genes mutate, they provide faulty instructions leading to production of abnormal huntingtin proteins and these form into clumps. 
  • The clumps disrupt the normal functioning of the brain cells, which eventually leads to death of neurons in the brain, resulting in Huntington disease.

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