Strict regulations are in place to control threats to animal health, human safety, and biodiversity at large during the processes of development, cultivation and transboundary movement of GM crops.
Acts and rules that regulate GM crops in India include:
- Environment Protection Act, 1986 (EPA)
- Biological Diversity Act, 2002
- Plant Quarantine Order, 2003
- GM policy under Foreign Trade Policy
- Food Safety and Standards Act, 2006
- Drugs and Cosmetics Rule (8th Amendment), 1988

Broadly, the rules cover:
- All activities related to research and development of GMOs
- Field and clinical trials of GMOs
- Deliberate or unintentional release of GMOs
- Import, export, and manufacture of GMOs