AlphaFold

In News: DeepMind, a company based in London and owned by Google, announced that it had predicted the three-dimensional structures of more than 200 million proteins using AlphaFold.

• This is the entire protein universe known to scientists today.

What is AlphaFold?

• AlphaFold is an AI-based protein structure prediction tool.
• It is based on a computer system called deep neural network.
• Inspired by the human brain, neural networks use a large amount of input data and provides the desired output exactly like how a human brain would.
• The real work is done by the black box between the input and the output layers, called the hidden networks.
• AlphaFold is fed with protein sequences as input.
• When protein sequences enter through one end, the predicted three-dimensional structures come out through the other.

How does AlphaFold work?

• It uses processes based on “training, learning, retraining and relearning.”
• The first step uses the available structures of 1,70,000 proteins in the Protein Data Bank (PDB) to train the computer model.
• Then, it uses the results of that training to learn the structural predictions of proteins not in the PDB.
• Then, it uses the high-accuracy predictions from the first step to retrain and relearn to gain higher accuracy of the earlier predictions.
• By using this method, AlphaFold has now predicted the structures of the entire 214 million unique protein sequences deposited in the Universal Protein Resource (UniProt) database.

What are the implications of this development?

• Proteins are the business ends of biology, meaning proteins carry out all the functions inside a living cell.
• Therefore, knowing protein structure and function is essential to understanding human diseases.
• The development of AlphaFold is a watershed movement in science and structural biology in particular.
• AlphaFold has already helped hundreds of scientists accelerate their discoveries in vaccine and drug development since the first public release of the database nearly a year back.

What does this development mean for India?

The Indian community of structural biology is strong and skilled.

• It needs to quickly take advantage of the AlphaFold database and learn how to use the structures to design better vaccines and drugs.
• India will also need to speed up its implementation of public-private partnerships in the sciences.
• The public-private partnership between the European Molecular Biology Laboratory’s European Bioinformatics Institute and DeepMind made the 25-terabyte AlphaFold dataset accessible to everyone in the scientific community at no cost.
• India could facilitate joint collaborations with the prevalent hardware muscle and data science talent in the private sector and specialists in academic institutions to pave the way for data science innovations.

Source: The Hindu

Previous Year Question

Q.1) The term ‘ACE2’ is talked about in the context of (2021)

1. genes introduced in the genetically modified plants
2. development of India’s own satellite navigation system
3. radio collar for wildlife tracking
4. spread of viral diseases