Huntington disease (HD) is a progressive genetic disorder affecting the brain
It causes uncontrolled movements, impaired coordination of balance and movement, a decline in cognitive abilities, difficulty in concentrating and memory lapses, mood swings and personality changes
How is the disease caused?
A gene called HTT are involved in the production of a protein called huntingtin.
When these genes mutate, they provide faulty instructions leading to production of abnormal huntingtin proteins and these form into clumps.
The clumps disrupt the normal functioning of the brain cells, which eventually leads to death of neurons in the brain, resulting in Huntington disease.
