Computation Analysis of Indian Genes published

  • IASbaba
  • November 1, 2020
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Computation Analysis of Indian Genes published

Part of: GS Prelims and GS-III – Science and Technology 

In news

  • Recently, the results from the computation analysis of the 1029 sequenced genomes from India were published in the scientific journal, Nucleic Acid Research.
  • The analysis was carried out by CSIR constituent labs, Institute of Genomics and Integrative Biology (IGIB), Delhi and Centre for Cellular and Molecular Biology (CCMB), Hyderabad.
  • The analysis has found that out of approximately 55.8 million single nucleotide variants in India, around 18.01 million (32.23%) variants are unique and found only in the samples sequenced from India.
  • Thus, India-centric population genomic initiative becomes important.

Important value additions 


  • A genome is all the genetic matter in an organism. 
  • It is defined as an organism’s complete set of DNA including all of its genes.
  • Every organism’s genetic code is contained in its DNA, the building blocks of life.
  • Each genome contains all of the information needed to build and maintain that organism.
  • In humans, a copy of the entire genome contains more than 3 billion DNA base pairs.

Genome sequencing

  • It means figuring out the order of Adenine, Cytosine, Guanines, and Thymine (DNA nucleotides) in a genome
  • Application: (1) Crucial role for new advancements in medical science; (2) In disease management; (3) Researchers and clinicians can easily detect the disease related to genetic disorder.
  • The study of entire genome sequences will help understand how genes work together to direct the growth, development and maintenance of an entire organism.
  • The genes account for less than 25% of the DNA in the Genome. Thus, knowing the entire genome sequence will help scientists study the parts of the genome outside the genes.

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